our new review in Trends in Genetics

Spermatogenesis and the Evolution of Mammalian Sex Chromosomes

Erica L. Larson, Emily E.K. Kopania, and Jeffrey M. Good  

Developmental constraint and sexual conflict shape the evolution of hetero- morphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermato- genesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromo- some gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development. PAPER

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Our preprint on mouse sperm morphology!

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A collaboration with Peter Ellis' group to quantify sperm nuclear morphology in classic and wild mice. Preprint. 

A high-throughput method for unbiased quantitation and categorisation of nuclear morphology

Benjamin Matthew Skinner, Claudia Cattoni Rathje, Joanne Bacon, Emma Elizabeth Philippa Johnson, Erica Lee Larson, Emily Emiko Konishi Kopania, Jeffrey Martin Good, Gullalaii Yousafzai, Nabeel Ahmed Affara, Peter James Ivor Ellis

 

Cover of Mammalian Genome

Our new paper presenting whole exomes of a set of mouse strains that harbor more variation than existing mouse resources, demonstrating these new data can improve our power to link genotype to phenotype in house mice.

Whole Exome Sequencing Of Wild-Derived Inbred Strains Of Mice Improves Power To Link Phenotype And Genotype

Peter L. Chang, Emily Kopania, Sara Keeble, Brice A. J. Sarver, Erica Larson, Annie Orth, Khalid Belkhir, Pierre Boursot, François Bonhomme, Jeffrey M. Good, Matthew D. Dean

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