DU delegates visited the University of Western Australia. The highlight of the trip was kangaroos!
Spermatogenesis and the Evolution of Mammalian Sex Chromosomes
Erica L. Larson, Emily E.K. Kopania, and Jeffrey M. Good
Developmental constraint and sexual conflict shape the evolution of hetero- morphic sex chromosomes. These contrasting forces are perhaps strongest during spermatogenesis in species with XY males. In this review, we consider how the unique regulatory environment and selective pressures of spermato- genesis interact to impact sex chromosome evolution in mammals. We explore how each developmental phase of spermatogenesis influences sex chromo- some gene content, structure, and rate of molecular evolution, and how these attributes may contribute to speciation. We argue that a developmental context is fundamental to understanding sex chromosome evolution and that an evolutionary perspective can shed new light on our understanding of sperm development. PAPER
The Murphy, Tinghitella and Larson Labs have been sampling clover across Denver as part of the Global Urban Evolution Project. We had great help from Veronica Huizar and Gui Zheng, who are participating in the University of Denver STEM Student Research Initiative. Check out Veronica and Gui's blogs about their summer research experience!
We review the Biology of Spermatozoa 2017 meeting, just in time to start planning on attending BoS 2019! Article Here
Finding sperm in the English Countryside
The 14th Biology of Spermatozoa Meeting
John L. Fitzpatrick and Erica L. Larson
A collaboration with Peter Ellis' group to quantify sperm nuclear morphology in classic and wild mice. Preprint.
A high-throughput method for unbiased quantitation and categorisation of nuclear morphology
Benjamin Matthew Skinner, Claudia Cattoni Rathje, Joanne Bacon, Emma Elizabeth Philippa Johnson, Erica Lee Larson, Emily Emiko Konishi Kopania, Jeffrey Martin Good, Gullalaii Yousafzai, Nabeel Ahmed Affara, Peter James Ivor Ellis
Re-thinking incompatibilities as fixed between species
The Evolution Of Polymorphic Hybrid Incompatibilities In House Mice
Erica L. Larson, Dan Vanderpool, Brice A. J. Sarver, Colin Callahan, Sara Keeble, Lorraine P. Provencio, Michael D. Kessler, Vanessa Stewart, Erin Nordquist, Matthew D. Dean and Jeffrey M. Good
Our new paper presenting whole exomes of a set of mouse strains that harbor more variation than existing mouse resources, demonstrating these new data can improve our power to link genotype to phenotype in house mice.
Whole Exome Sequencing Of Wild-Derived Inbred Strains Of Mice Improves Power To Link Phenotype And Genotype
Peter L. Chang, Emily Kopania, Sara Keeble, Brice A. J. Sarver, Erica Larson, Annie Orth, Khalid Belkhir, Pierre Boursot, François Bonhomme, Jeffrey M. Good, Matthew D. Dean